Cell Senescence Entries for MDH1
- Cell Types
- Dermal fibroblast, Lung fibroblast
- Cell Lines
- IMR-90, Primary cell
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Lee et al. (2013) Cytosolic malate dehydrogenase regulates senescence in human fibroblasts. Biogerontology 13(5)525-36 (PubMed)
MDH1 Gene Information
- HGNC symbol
- MDH1
- Aliases
- Common name
- malate dehydrogenase 1
- Entrez Id
- 4190
- Description
- This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq, Feb 2016].
MDH1 Ontologies
- Gene Ontology
-
Process: GO:6099; tricarboxylic acid cycle
GO:6108; malate metabolic process
GO:19752; carboxylic acid metabolic process
GO:6734; NADH metabolic process
GO:6107; oxaloacetate metabolic process
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5615; extracellular space
GO:5813; centrosome
GO:70062; extracellular exosome
Show all GO termsFunction: GO:16491; oxidoreductase activity
GO:3824; catalytic activity
GO:16616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:5515; protein binding
GO:16615; malate dehydrogenase activity
GO:30060; L-malate dehydrogenase activity
GO:4470; malic enzyme activity
GO:47860; diiodophenylpyruvate reductase activity
Homologs of MDH1 in Model Organisms
- Caenorhabditis elegans
- mdh-1
- Danio rerio
- mdh1ab
- Danio rerio
- mdh1aa
- Drosophila melanogaster
- Mdh1
- Mus musculus
- Mdh1
- Rattus norvegicus
- Mdh1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as mdh-1
- GenAge microarray genes
- This gene is present as MDH1
External links
- OMIM
- 154200
- Ensembl
- ENSG00000014641
- Entrez Gene
- 4190
- UniGene
- 526521
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- MDH1
- GeneCards
- MDH1