Cell Senescence Entries for KL
- Cell Types
- Lung fibroblast
- Cell Lines
- MRC-5, WI-38
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- de Oliveira et al. (2006) Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway. FEBS Lett 580(24)5753-8 (PubMed)
KL Gene Information
- HGNC symbol
- KL
- Aliases
- KLA
- Common name
- klotho
- Entrez Id
- 9365
- Description
- This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008].
KL Ontologies
- Gene Ontology
-
Process: GO:5975; carbohydrate metabolic process
GO:8152; metabolic process
GO:8543; fibroblast growth factor receptor signaling pathway
GO:7568; aging
GO:30501; positive regulation of bone mineralization
GO:8286; insulin receptor signaling pathway
GO:2526; acute inflammatory response
GO:3085; negative regulation of systemic arterial blood pressure
GO:6112; energy reserve metabolic process
GO:14823; response to activity
GO:33280; response to vitamin D
And 6 more GO terms Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5615; extracellular space
GO:5886; plasma membrane
GO:5576; extracellular region
GO:16324; apical plasma membrane
GO:70062; extracellular exosome
GO:5887; integral component of plasma membrane
Function: GO:16787; hydrolase activity
GO:4553; hydrolase activity, hydrolyzing O-glycosyl compounds
GO:16798; hydrolase activity, acting on glycosyl bonds
GO:5179; hormone activity
GO:5499; vitamin D binding
GO:5104; fibroblast growth factor receptor binding
GO:17134; fibroblast growth factor binding
GO:4566; beta-glucuronidase activity
GO:8422; beta-glucosidase activity
Homologs of KL in Model Organisms
- Caenorhabditis elegans
- klo-2
- Caenorhabditis elegans
- klo-1
- Danio rerio
- kl
- Mus musculus
- Kl
- Rattus norvegicus
- Kl
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as KL
- LongevityMap
- This gene is present as KL
External links
- OMIM
- 604824
- Ensembl
- ENSG00000133116
- Entrez Gene
- 9365
- UniGene
- 524953
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- KL
- GeneCards
- KL