Cell Senescence Entries for ING1

Cell Types
Foreskin fibroblast
Cell Lines
HS68
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Soliman et al. (2009) ING1a expression increases during replicative senescence and induces a senescent phenotype. Aging Cell 7(6)783-94 (PubMed)

ING1 Gene Information

HGNC symbol
ING1 
Aliases
p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a 
Common name
inhibitor of growth family member 1 
Entrez Id
3621
Description
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

ING1 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:8285; negative regulation of cell population proliferation
GO:10941; regulation of cell death
GO:30308; negative regulation of cell growth
GO:6355; regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:30336; negative regulation of cell migration
GO:1902459; positive regulation of stem cell population maintenance
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:1902455; negative regulation of stem cell population maintenance
And 3 more GO terms
Cellular component: GO:5634; nucleus
GO:16580; Sin3 complex
Function: GO:46872; metal ion binding
GO:5515; protein binding
GO:35064; methylated histone binding
Show all GO terms

Homologs of ING1 in Model Organisms

Caenorhabditis elegans
Y43H11AL.1
Caenorhabditis elegans
ing-3
Danio rerio
ing1
Drosophila melanogaster
CG7379
Mus musculus
Ing1
Rattus norvegicus
Ing1
Saccharomyces cerevisiae
PHO23
Schizosaccharomyces pombe
png2

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as PHO23

External links

OMIM
601566
Ensembl
ENSG00000153487
Entrez Gene
3621
UniGene
508725
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ING1
GeneCards
ING1