Cell Senescence Entries for HSPA9

Cell Types
Breast cancer, Osteosarcoma
Cell Lines
MCF-7, U2OS
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Deocaris et al. (2007) Mortalin sensitizes human cancer cells to MKT-077-induced senescence. Cancer Lett 252(2)259-69 (PubMed)

HSPA9 Gene Information

HGNC symbol
HSPA9 
Aliases
GRP75; HSPA9B; mot-2; mthsp75; PBP74 
Common name
heat shock protein family A (Hsp70) member 9 
Entrez Id
3313
Description
This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010].

HSPA9 Ontologies

Gene Ontology
Process: GO:6457; protein folding
GO:43066; negative regulation of apoptotic process
GO:16226; iron-sulfur cluster assembly
GO:30218; erythrocyte differentiation
GO:6611; protein export from nucleus
GO:1902037; negative regulation of hematopoietic stem cell differentiation
GO:1903707; negative regulation of hemopoiesis
GO:7007; inner mitochondrial membrane organization
GO:51085; chaperone cofactor-dependent protein refolding
GO:45646; regulation of erythrocyte differentiation
GO:34620; cellular response to unfolded protein
And 4 more GO terms
Cellular component: GO:5634; nucleus
GO:5739; mitochondrion
GO:5925; focal adhesion
GO:5730; nucleolus
GO:5737; cytoplasm
GO:5759; mitochondrial matrix
GO:70062; extracellular exosome
GO:5743; mitochondrial inner membrane
GO:42645; mitochondrial nucleoid
GO:1401; SAM complex
GO:140275; MIB complex
And 2 more GO terms
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16887; ATP hydrolysis activity
GO:51082; unfolded protein binding
GO:3723; RNA binding
GO:5515; protein binding
GO:19899; enzyme binding
GO:31625; ubiquitin protein ligase binding
GO:44183; protein folding chaperone
GO:31072; heat shock protein binding
GO:51787; misfolded protein binding
And 1 more GO terms
Show all GO terms

Homologs of HSPA9 in Model Organisms

Caenorhabditis elegans
hsp-6
Danio rerio
hspa9
Drosophila melanogaster
Hsc70-5
Mus musculus
Hspa9
Rattus norvegicus
Hspa9
Saccharomyces cerevisiae
SSC1
Schizosaccharomyces pombe
ssp1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as hsp-6
  • A homolog of this gene for Saccharomyces cerevisiae is present as SSC1
GenAge human genes
  • This gene is present as HSPA9

External links

OMIM
600548
Ensembl
ENSG00000113013
Entrez Gene
3313
UniGene
184233
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HSPA9
GeneCards
HSPA9