Cell Senescence Entries for HDAC3
- Cell Types
- Lung cancer
- Cell Lines
- NCI-H460
- Cancer Cell?
- Yes
- Method
- Knockdown, Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Wang et al. (2008) YY1 restrained cell senescence through repressing the transcription of p16. Biochim Biophys Acta 1783(10)1876-83 (PubMed)
HDAC3 Gene Information
- HGNC symbol
- HDAC3
- Aliases
- HD3; KDAC3; RPD3; RPD3-2
- Common name
- histone deacetylase 3
- Entrez Id
- 8841
- Description
- Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008].
HDAC3 Ontologies
- Gene Ontology
-
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6476; protein deacetylation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1934; positive regulation of protein phosphorylation
GO:16575; histone deacetylation
GO:122; negative regulation of transcription by RNA polymerase II
GO:48511; rhythmic process
GO:32922; circadian regulation of gene expression
GO:6357; regulation of transcription by RNA polymerase II
GO:31398; positive regulation of protein ubiquitination
And 10 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5829; cytosol
GO:118; histone deacetylase complex
GO:72686; mitotic spindle
GO:17053; transcription repressor complex
Function: GO:5515; protein binding
GO:16787; hydrolase activity
GO:19899; enzyme binding
GO:4407; histone deacetylase activity
GO:42826; histone deacetylase binding
GO:140297; DNA-binding transcription factor binding
GO:3682; chromatin binding
GO:3714; transcription corepressor activity
GO:1222; transcription corepressor binding
GO:30332; cyclin binding
GO:33558; protein deacetylase activity
And 2 more GO terms
Homologs of HDAC3 in Model Organisms
- Danio rerio
- hdac3
- Drosophila melanogaster
- Hdac3
- Mus musculus
- Hdac3
- Rattus norvegicus
- Hdac3
- Saccharomyces cerevisiae
- RPD3
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as RPD3
- GenAge human genes
- This gene is present as HDAC3
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as RPD3
External links
- OMIM
- 605166
- Ensembl
- ENSG00000171720
- Entrez Gene
- 8841
- UniGene
- 519632
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- HDAC3
- GeneCards
- HDAC3