Cell Senescence Entries for HDAC3

Cell Types
Lung cancer
Cell Lines
NCI-H460
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Wang et al. (2008) YY1 restrained cell senescence through repressing the transcription of p16. Biochim Biophys Acta 1783(10)1876-83 (PubMed)

HDAC3 Gene Information

HGNC symbol
HDAC3 
Aliases
HD3; KDAC3; RPD3; RPD3-2 
Common name
histone deacetylase 3 
Entrez Id
8841
Description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008].

HDAC3 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6476; protein deacetylation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1934; positive regulation of protein phosphorylation
GO:16575; histone deacetylation
GO:122; negative regulation of transcription by RNA polymerase II
GO:48511; rhythmic process
GO:32922; circadian regulation of gene expression
GO:6357; regulation of transcription by RNA polymerase II
GO:31398; positive regulation of protein ubiquitination
And 10 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5829; cytosol
GO:118; histone deacetylase complex
GO:72686; mitotic spindle
GO:17053; transcription repressor complex
Function: GO:5515; protein binding
GO:16787; hydrolase activity
GO:19899; enzyme binding
GO:4407; histone deacetylase activity
GO:42826; histone deacetylase binding
GO:140297; DNA-binding transcription factor binding
GO:3682; chromatin binding
GO:3714; transcription corepressor activity
GO:1222; transcription corepressor binding
GO:30332; cyclin binding
GO:33558; protein deacetylase activity
And 2 more GO terms
Show all GO terms

Homologs of HDAC3 in Model Organisms

Danio rerio
hdac3
Drosophila melanogaster
Hdac3
Mus musculus
Hdac3
Rattus norvegicus
Hdac3
Saccharomyces cerevisiae
RPD3

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as RPD3
GenAge human genes
  • This gene is present as HDAC3
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as RPD3

External links

OMIM
605166
Ensembl
ENSG00000171720
Entrez Gene
8841
UniGene
519632
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HDAC3
GeneCards
HDAC3