Cell Senescence Entries for FOXO3
- Cell Types
- Dermal fibroblast
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Kyoung Kim et al. (2005) Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblasts. J Gerontol A Biol Sci Med Sci 60(1)4-9 (PubMed)
FOXO3 Gene Information
- HGNC symbol
- FOXO3
- Aliases
- AF6q21; FKHRL1; FOXO2; FOXO3A
- Common name
- forkhead box O3
- Entrez Id
- 2309
- Description
- This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
FOXO3 Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:6417; regulation of translation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:33209; tumor necrosis factor-mediated signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:10508; positive regulation of autophagy
GO:34599; cellular response to oxidative stress
GO:122; negative regulation of transcription by RNA polymerase II
GO:6390; mitochondrial transcription
And 37 more GO terms Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5739; mitochondrion
GO:5759; mitochondrial matrix
GO:5741; mitochondrial outer membrane
GO:5829; cytosol
GO:785; chromatin
GO:90571; RNA polymerase II transcription repressor complex
And 1 more GO terms Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:31490; chromatin DNA binding
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:19901; protein kinase binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:976; transcription cis-regulatory region binding
And 5 more GO terms
Homologs of FOXO3 in Model Organisms
- Caenorhabditis elegans
- daf-16
- Danio rerio
- foxo3a
- Danio rerio
- foxo3b
- Drosophila melanogaster
- foxo
- Mus musculus
- Foxo3
- Rattus norvegicus
- Foxo3
- Saccharomyces cerevisiae
- HCM1
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as FOXO3
- GenDR gene manipulations
- LongevityMap
- This gene is present as FOXO3
External links
- OMIM
- 602681
- Ensembl
- ENSG00000118689
- Entrez Gene
- 2309
- UniGene
- 220950
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- FOXO3
- GeneCards
- FOXO3