Cell Senescence Entries for EGR2
- Cell Types
- Mammary epithelial
- Cell Lines
- IMR-90, Primary cell, WI-38
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Tyler et al. (2021) Early growth response 2 (EGR2) is a novel regulator of the senescence programme. Aging Cell 20(3)e13318 (PubMed)
EGR2 Gene Information
- HGNC symbol
- EGR2
- Aliases
- KROX20
- Common name
- early growth response 2
- Entrez Id
- 1959
- Description
- The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
EGR2 Ontologies
- Gene Ontology
-
Process: GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:16925; protein sumoylation
GO:6357; regulation of transcription by RNA polymerase II
GO:7420; brain development
GO:7422; peripheral nervous system development
GO:6611; protein export from nucleus
GO:45444; fat cell differentiation
GO:35914; skeletal muscle cell differentiation
GO:31643; positive regulation of myelination
GO:6355; regulation of transcription, DNA-templated
And 20 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:785; chromatin
Function: GO:46872; metal ion binding
GO:16740; transferase activity
GO:3677; DNA binding
GO:31625; ubiquitin protein ligase binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:3682; chromatin binding
And 6 more GO terms
Homologs of EGR2 in Model Organisms
- Caenorhabditis elegans
- egrh-2
- Caenorhabditis elegans
- egrh-1
- Danio rerio
- egr2b
- Danio rerio
- egr2a
- Danio rerio
- egr2a
- Danio rerio
- egr2a
- Drosophila melanogaster
- sr
- Mus musculus
- Egr2
- Rattus norvegicus
- Egr2
- Saccharomyces cerevisiae
- MIG3
- Saccharomyces cerevisiae
- MIG1
- Saccharomyces cerevisiae
- MIG2
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as MIG1
External links
- OMIM
- 129010
- Ensembl
- ENSG00000122877
- Entrez Gene
- 1959
- UniGene
- 1395
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- EGR2
- GeneCards
- EGR2