Cell Senescence Entries for E2F1
- Cell Types
- Lung fibroblast
- Cell Lines
- WI-38
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Dimri et al. (2000) Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol Cell Biol 20(1)273-85 (PubMed)
E2F1 Gene Information
- HGNC symbol
- E2F1
- Aliases
- RBBP3; RBP3
- Common name
- E2F transcription factor 1
- Entrez Id
- 1869
- Description
- The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008].
E2F1 Ontologies
- Gene Ontology
-
Process: GO:10628; positive regulation of gene expression
GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:6357; regulation of transcription by RNA polymerase II
GO:45892; negative regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:43065; positive regulation of apoptotic process
GO:6351; transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
And 24 more GO terms Cellular component: GO:5634; nucleus
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5813; centrosome
GO:5667; transcription regulator complex
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:35189; Rb-E2F complex
GO:5737; cytoplasm
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:987; cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1216; DNA-binding transcription activator activity
And 3 more GO terms
Homologs of E2F1 in Model Organisms
- Caenorhabditis elegans
- efl-2
- Danio rerio
- E2F1
- Drosophila melanogaster
- E2f1
- Mus musculus
- E2f1
- Rattus norvegicus
- E2f1
- Rattus norvegicus
- E2f1
In other databases
- GenAge human genes
- This gene is present as E2F1
External links
- OMIM
- 189971
- Ensembl
- ENSG00000101412
- Entrez Gene
- 1869
- UniGene
- 654393
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- E2F1
- GeneCards
- E2F1