Cell Senescence Entries for CCN2

Cell Types
Breast cancer, Foreskin fibroblast
Cell Lines
HTERT-BJ1, MDA-MB-231
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Capparelli et al. (2012) CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Cell Cycle 11(12)2272-84 (PubMed)

CCN2 Gene Information

HGNC symbol
CCN2 
Aliases
CTGF; IGFBP8 
Common name
cellular communication network factor 2 
Entrez Id
1490
Description
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009].

CCN2 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:7155; cell adhesion
GO:71897; DNA biosynthetic process
GO:9611; response to wounding
GO:46330; positive regulation of JNK cascade
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:60548; negative regulation of cell death
GO:51496; positive regulation of stress fiber assembly
GO:8544; epidermis development
GO:45597; positive regulation of cell differentiation
GO:1502; cartilage condensation
And 36 more GO terms
Cellular component: GO:5576; extracellular region
GO:31012; extracellular matrix
GO:62023; collagen-containing extracellular matrix
GO:5886; plasma membrane
GO:5615; extracellular space
GO:5801; cis-Golgi network
GO:5829; cytosol
GO:5938; cell cortex
GO:48471; perinuclear region of cytoplasm
Function: GO:5515; protein binding
GO:8201; heparin binding
GO:8022; protein C-terminus binding
GO:5178; integrin binding
GO:5520; insulin-like growth factor binding
GO:1968; fibronectin binding
GO:8083; growth factor activity
Show all GO terms

Homologs of CCN2 in Model Organisms

Danio rerio
ctgfa
Drosophila melanogaster
Ccn
Mus musculus
Ctgf
Rattus norvegicus
Ctgf

In other databases

GenAge human genes
  • This gene is present as CTGF
GenAge microarray genes
  • This gene is present as CCN2
GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Ctgf
CellAge gene expression
  • This gene is present as CTGF

External links

OMIM
121009
Ensembl
ENSG00000118523
Entrez Gene
1490
UniGene
410037
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CCN2
GeneCards
CCN2