Cell Senescence Entries for ATG7
- Cell Types
- Foreskin fibroblast, Lung fibroblast
- Cell Lines
- BJ, IMR-90
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Young et al. (2009) Autophagy mediates the mitotic senescence transition. Genes Dev 23(7)798-803 (PubMed)
ATG7 Gene Information
- HGNC symbol
- ATG7
- Aliases
- APG7L; DKFZp434N0735; GSA7
- Common name
- autophagy related 7
- Entrez Id
- 10533
- Description
- This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
ATG7 Ontologies
- Gene Ontology
-
Process: GO:15031; protein transport
GO:6914; autophagy
GO:48511; rhythmic process
GO:43065; positive regulation of apoptotic process
GO:32446; protein modification by small protein conjugation
GO:45; autophagosome assembly
GO:422; autophagy of mitochondrion
GO:6995; cellular response to nitrogen starvation
GO:9267; cellular response to starvation
GO:45732; positive regulation of protein catabolic process
GO:44805; late nucleophagy
And 10 more GO terms Cellular component: GO:5737; cytoplasm
GO:407; phagophore assembly site
GO:5930; axoneme
GO:5576; extracellular region
GO:5829; cytosol
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
Function: GO:8641; ubiquitin-like modifier activating enzyme activity
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:19778; Atg12 activating enzyme activity
GO:19779; Atg8 activating enzyme activity
Homologs of ATG7 in Model Organisms
- Caenorhabditis elegans
- atg-7
- Danio rerio
- atg7
- Drosophila melanogaster
- Atg7
- Mus musculus
- Atg7
- Rattus norvegicus
- Atg7
- Saccharomyces cerevisiae
- ATG7
- Schizosaccharomyces pombe
- atg7
In other databases
- GenAge model organism genes
- GenDR gene manipulations
External links
- OMIM
- 608760
- Ensembl
- ENSG00000197548
- Entrez Gene
- 10533
- UniGene
- 38032
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ATG7
- GeneCards
- ATG7