Cell Senescence Entries for ARRB1

Cell Types
T-cell leukemia
Cell Lines
Jurkat
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Guo et al. (2019) [β-arrestin 1 Promotes Senescence of Acute Lymphoblastic Leukemia Jurkat Cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 27(3)777-784 (PubMed)

ARRB1 Gene Information

HGNC symbol
ARRB1 
Aliases
ARR1 
Common name
arrestin beta 1 
Entrez Id
408
Description
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011].

ARRB1 Ontologies

Gene Ontology
Process: GO:15031; protein transport
GO:16567; protein ubiquitination
GO:7165; signal transduction
GO:50790; regulation of catalytic activity
GO:9968; negative regulation of signal transduction
GO:1934; positive regulation of protein phosphorylation
GO:43086; negative regulation of catalytic activity
GO:6511; ubiquitin-dependent protein catabolic process
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:6357; regulation of transcription by RNA polymerase II
GO:32717; negative regulation of interleukin-8 production
And 13 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5905; clathrin-coated pit
GO:31410; cytoplasmic vesicle
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:16604; nuclear body
GO:42995; cell projection
GO:5829; cytosol
GO:139; Golgi membrane
And 5 more GO terms
Function: GO:31625; ubiquitin protein ligase binding
GO:5096; GTPase activator activity
GO:5515; protein binding
GO:1664; G protein-coupled receptor binding
GO:3713; transcription coactivator activity
GO:8134; transcription factor binding
GO:5159; insulin-like growth factor receptor binding
GO:4857; enzyme inhibitor activity
GO:31701; angiotensin receptor binding
GO:1990763; arrestin family protein binding
Show all GO terms

Homologs of ARRB1 in Model Organisms

Caenorhabditis elegans
arr-1
Danio rerio
arrb1
Drosophila melanogaster
krz
Drosophila melanogaster
Arr2
Drosophila melanogaster
CG32683
Drosophila melanogaster
Arr1
Mus musculus
Arrb1
Rattus norvegicus
Arrb1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as arr-1

External links

OMIM
107940
Ensembl
ENSG00000137486
Entrez Gene
408
UniGene
625320
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ARRB1
GeneCards
ARRB1