Cell Senescence Entries for AKT3

Cell Types
Bladder cancer
Cell Lines
EJ138
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2017) Akt3 knockdown induces mitochondrial dysfunction in human cancer cells. Acta Biochim Biophys Sin (Shanghai) 48(5)447-53 (PubMed)

AKT3 Gene Information

HGNC symbol
AKT3 
Aliases
PKBG; PRKBG; RAC-gamma 
Common name
AKT serine/threonine kinase 3 
Entrez Id
10000
Description
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

AKT3 Ontologies

Gene Ontology
Process: GO:2000773; negative regulation of cellular senescence
GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:35556; intracellular signal transduction
GO:7165; signal transduction
GO:18105; peptidyl-serine phosphorylation
GO:1938; positive regulation of endothelial cell proliferation
GO:90050; positive regulation of cell migration involved in sprouting angiogenesis
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:1905564; positive regulation of vascular endothelial cell proliferation
GO:2; mitochondrial genome maintenance
And 7 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
Show all GO terms

Homologs of AKT3 in Model Organisms

Caenorhabditis elegans
akt-1
Caenorhabditis elegans
akt-2
Danio rerio
akt3b
Danio rerio
akt3a
Drosophila melanogaster
Akt1
Mus musculus
Akt3
Rattus norvegicus
Akt3
Saccharomyces cerevisiae
SCH9
Saccharomyces cerevisiae
YPK1
Saccharomyces cerevisiae
YPK2

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as akt-1
  • A homolog of this gene for Saccharomyces cerevisiae is present as SCH9
  • A homolog of this gene for Drosophila melanogaster is present as Akt1
  • A homolog of this gene for Saccharomyces cerevisiae is present as YPK1
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as SCH9
LongevityMap
  • This gene is present as AKT3

External links

OMIM
611223
Ensembl
ENSG00000117020
Entrez Gene
10000
UniGene
498292
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AKT3
GeneCards
AKT3