LongevityMap Gene
Gene details
- HGNC symbol
- ZFP57
- Aliases
- TNDM1; ZNF698; C6orf40; bA145L22; bA145L22.2
- Common name
- ZFP57 zinc finger protein
- Description
- The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009]
- Cytogenetic Location
- 6p22.1
- UCSC Genome Browser
- View 6p22.1 on the UCSC genome browser
- OMIM
- 612192
- Ensembl
- ENSG00000204644
- UniProt/Swiss-Prot
- B7ZW61_HUMAN
- Entrez Gene
- 346171
- UniGene
- 156326
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Mus musculus
- Zfp57
- Rattus norvegicus
- Zfp57
- Rattus norvegicus
- AABR07055919.1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
- Conclusions
- Fifteen SNPs had indicative association with longevity, even if not statistically significant after correcting for multiple hypothesis testing. None of these SNPs were validated in the follow-up analysis. Since rs12741354 (in ASTN1) was nearly significant, it was further investigated in French centenarians but it failed to be associated with longevity.
- Indentifier
- rs3129063
- Reference