LongevityMap Gene
Gene details
- HGNC symbol
- YY1
- Aliases
- DELTA; NF-E1; UCRBP; INO80S; YIN-YANG-1
- Common name
- YY1 transcription factor
- Description
- YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 14q32.2
- UCSC Genome Browser
- View 14q32.2 on the UCSC genome browser
- OMIM
- 600013
- Ensembl
- ENSG00000100811
- UniProt/Swiss-Prot
- TYY1_HUMAN
- Entrez Gene
- 7528
- UniGene
- 388927
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- CellAge
- This gene is present as YY1
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- YY1
- Reference