LongevityMap Gene

Gene details

HGNC symbol: TSPAN32
Aliases: ART1; PHMX; PHEMX; TSSC6
Common name: tetraspanin 32
Description: This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 11p15.5
UCSC Genome Browser: View 11p15.5 on the UCSC genome browser
OMIM: 603853
Ensembl: ENSG00000064201
UniProt/Swiss-Prot: TSN32_HUMAN
Entrez Gene: 10077
UniGene: 271954
1000 Genomes: 1000 Genomes

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

European

Study Design

The chromosomal region 11p.15.5 was investigated in 1321 centenarians and 1140 younger subjects from European samples

Conclusions

A meta-analysis approach revealed suggestive signals in 6 SNPs

Indentifier

rs800140

Reference