LongevityMap Gene
Gene details
- HGNC symbol
- SNCA
- Aliases
- PD1; NACP; PARK1; PARK4
- Common name
- synuclein alpha
- Description
- Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
- Cytogenetic Location
- 4q22.1
- UCSC Genome Browser
- View 4q22.1 on the UCSC genome browser
- OMIM
- 163890
- Ensembl
- ENSG00000145335
- UniProt/Swiss-Prot
- H6UYS5_HUMAN
- Entrez Gene
- 6622
- UniGene
- 21374
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American (Caucasian)
- Study Design
- Twenty SNCA variants were examined in 769 controls without neurological disease (Mean age: 79 years, Range: 33-99 years) for frequency differences across across age groups
- Conclusions
- No significant associations were found after correcting for multiple testing, though rs10014396 and rs3775439 had a suggestive change with age in frequency
- Indentifier
- rs10014396
- Reference