LongevityMap Gene

Gene details

HGNC symbol: SLC6A3
Aliases: DAT; DAT1; PKDYS
Common name: solute carrier family 6 member 3
Description: This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]
Cytogenetic Location: 5p15.33
UCSC Genome Browser: View 5p15.33 on the UCSC genome browser
OMIM: 126455
Ensembl: ENSG00000142319
UniProt/Swiss-Prot: SC6A3_HUMAN
Entrez Gene: 6531
UniGene: 406
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: dat-1
Danio rerio: SLC6A3
Drosophila melanogaster: DAT
Mus musculus: Slc6a3
Rattus norvegicus: Slc6a3

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

Italian (Southern)

Study Design

A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).

Conclusions

After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.

Indentifier

rs2652511

Reference