LongevityMap Gene
Gene details
- HGNC symbol
- SLC2A4
- Aliases
- GLUT4
- Common name
- solute carrier family 2 member 4
- Description
- This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 17p13.1
- UCSC Genome Browser
- View 17p13.1 on the UCSC genome browser
- OMIM
- 138190
- Ensembl
- ENSG00000181856
- UniProt/Swiss-Prot
- GTR4_HUMAN
- Entrez Gene
- 6517
- UniGene
- 380691
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- F53H8.3
- Caenorhabditis elegans
- F48E3.2
- Caenorhabditis elegans
- K08F9.1
- Caenorhabditis elegans
- K08H10.6
- Caenorhabditis elegans
- slcf-2
- Caenorhabditis elegans
- Y37A1A.3
- Caenorhabditis elegans
- F14E5.1
- Caenorhabditis elegans
- C03B1.13
- Caenorhabditis elegans
- Y39E4B.5
- Caenorhabditis elegans
- ZK829.9
- Caenorhabditis elegans
- F13B12.2
- Caenorhabditis elegans
- Y61A9LA.1
- Caenorhabditis elegans
- C35A11.4
- Drosophila melanogaster
- Glut1
- Mus musculus
- Slc2a4
- Rattus norvegicus
- Slc2a4
- Saccharomyces cerevisiae
- VPS73
- Saccharomyces cerevisiae
- 852543
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs2654185
- Reference