LongevityMap Gene

Gene details

HGNC symbol: SHC1
Aliases: SHC; SHCA
Common name: SHC adaptor protein 1
Description: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Cytogenetic Location: 1q21.3
UCSC Genome Browser: View 1q21.3 on the UCSC genome browser
OMIM: 600560
Ensembl: ENSG00000160691
UniProt/Swiss-Prot: SHC1_HUMAN
Entrez Gene: 6464
UniGene: 433795
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: shc-1
Danio rerio: shc1
Drosophila melanogaster: Shc
Mus musculus: Shc1
Rattus norvegicus: Shc1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Shc1
A homolog of this gene for Caenorhabditis elegans is present as shc-1

GenAge human genes

This gene is present as SHC1

Studies (3)

Significant/Non-significant: 0/3

Study 1

Longevity Association

Non-significant

Population

Study Design

12 SNPs within a 10-kb region encompassing the entire SHC1 gene were examined in 230 Japanese centenarians and 180 healthy younger controls

Conclusions

The SNPs were not associated with longevity

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Study Design

Two independent cohorts of respectively 730 and 563 subjects aged 85 and over were tested for the association of Met(410)Val SNP with longevity using a prospective follow-up design

Conclusions

In the first cohort, increasing Val allele frequency was found with increasing age at death. Compared to Met/Met carriers, mortality rate was reduced in Met/Val carriers in the combined cohorts. These results were not statistically significant, however.

Indentifier

Reference

Study 3

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier