LongevityMap Gene
Gene details
- HGNC symbol
- RRAGD
- Aliases
- RAGD; bA11D8.2.1
- Common name
- Ras related GTP binding D
- Description
- RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.[supplied by OMIM, Apr 2004]
- Cytogenetic Location
- 6q15
- UCSC Genome Browser
- View 6q15 on the UCSC genome browser
- OMIM
- 608268
- Ensembl
- ENSG00000025039
- UniProt/Swiss-Prot
- RRAGD_HUMAN
- Entrez Gene
- 58528
- UniGene
- 31712
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- ragc-1
- Danio rerio
- rragd
- Drosophila melanogaster
- RagC-D
- Mus musculus
- Rragd
- Rattus norvegicus
- Rragd
- Saccharomyces cerevisiae
- GTR2
- Schizosaccharomyces pombe
- gtr2
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as ragc-1
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- RRAGD
- Reference