LongevityMap Gene
Gene details
- HGNC symbol
- RIC8A
- Aliases
- RIC8
- Common name
- RIC8 guanine nucleotide exchange factor A
- Description
- Cytogenetic Location
- 11p15.5
- UCSC Genome Browser
- View 11p15.5 on the UCSC genome browser
- OMIM
- 609146
- Ensembl
- ENSG00000177963
- UniProt/Swiss-Prot
- RIC8A_HUMAN
- Entrez Gene
- 60626
- UniGene
- 592292
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- ric-8
- Danio rerio
- ric8a
- Drosophila melanogaster
- ric8a
- Mus musculus
- Ric8a
- Rattus norvegicus
- Ric8a
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- European
- Study Design
- The chromosomal region 11p.15.5 was investigated in 1321 centenarians and 1140 younger subjects from European samples
- Conclusions
- No significant results were observed for genes previously associated with longevity, except for SIRT3. A replication study in a French population did not confirm earlier findings for SIRT3, however. A meta-analysis approach of SIRT3 SNPs did not reveal robust signals.
- Indentifier
- rs2293168
- Reference