LongevityMap Gene
Gene details
- HGNC symbol
- RHOA
- Aliases
- ARHA; ARH12; RHO12; RHOH12
- Common name
- ras homolog family member A
- Description
- This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
- Cytogenetic Location
- 3p21.31
- UCSC Genome Browser
- View 3p21.31 on the UCSC genome browser
- OMIM
- 165390
- Ensembl
- ENSG00000067560
- UniProt/Swiss-Prot
- A0A024R324_HUMAN
- Entrez Gene
- 387
- UniGene
- 247077
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- rho-1
- Danio rerio
- rhoaa
- Danio rerio
- rhoab
- Danio rerio
- rhoac
- Danio rerio
- rhoab
- Drosophila melanogaster
- Rho1
- Mus musculus
- 4930544G11Rik
- Rattus norvegicus
- RSA-14-44
- Saccharomyces cerevisiae
- RHO1
In other databases
- CellAge
- This gene is present as RHOA
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- RHOA
- Reference