LongevityMap Gene

Gene details

HGNC symbol: PSMD13
Aliases: S11; Rpn9; p40.5; HSPC027
Common name: proteasome 26S subunit, non-ATPase 13
Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 11p15.5
UCSC Genome Browser: View 11p15.5 on the UCSC genome browser
OMIM: 603481
Ensembl: ENSG00000185627
UniProt/Swiss-Prot: PSD13_HUMAN
Entrez Gene: 5719
UniGene: 134688
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: rpn-9
Danio rerio: psmd13
Drosophila melanogaster: Rpn9
Mus musculus: Psmd13
Rattus norvegicus: Psmd13
Saccharomyces cerevisiae: RPN9
Schizosaccharomyces pombe: rpn9

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

European

Study Design

The chromosomal region 11p.15.5 was investigated in 1321 centenarians and 1140 younger subjects from European samples

Conclusions

No significant results were observed for genes previously associated with longevity, except for SIRT3. A replication study in a French population did not confirm earlier findings for SIRT3, however. A meta-analysis approach of SIRT3 SNPs did not reveal robust signals.

Indentifier

rs559422

Reference