LongevityMap Gene

Gene details

HGNC symbol: PRKCA
Aliases: AAG6; PKCA; PRKACA; PKC-alpha
Common name: protein kinase C alpha
Description: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 17q24.2
UCSC Genome Browser: View 17q24.2 on the UCSC genome browser
OMIM: 176960
Ensembl: ENSG00000154229
UniProt/Swiss-Prot: KPCA_HUMAN
Entrez Gene: 5578
UniGene: 531704
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: pkc-2
Danio rerio: prkca
Danio rerio: PRKCA (1 of many)
Drosophila melanogaster: Pkc53E
Drosophila melanogaster: inaC
Mus musculus: Prkca
Rattus norvegicus: Prkca
Saccharomyces cerevisiae: PKC1

In other databases

GenAge human genes

This gene is present as PRKCA

Studies (3)

Significant/Non-significant: 1/2

Study 1

Longevity Association

Population

Study Design

1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls

Conclusions

As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing

Indentifier

Reference

Study 2

Longevity Association: Non-significant
Population: Italian
Study Design: Genome-wide association study on 410 long-living individuals (age range, 90–109 years) and 553 young control individuals (age range, 18–48 years) using 318,237 SNPs. An independent population with 116 long-lived individuals and 160 controls was used for replication purposes.
Conclusions: A total of 67 SNPs were identified with an indication of potentially being associated with longevity (p < 1 × 10−4), though 66 were not further validated
Indentifier

Study 3

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier