LongevityMap Gene
Gene details
- HGNC symbol
- PPARA
- Aliases
- PPAR; NR1C1; hPPAR; PPARalpha
- Common name
- peroxisome proliferator activated receptor alpha
- Description
- Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 22q13.31
- UCSC Genome Browser
- View 22q13.31 on the UCSC genome browser
- OMIM
- 170998
- Ensembl
- ENSG00000186951
- UniProt/Swiss-Prot
- F1D8S4_HUMAN
- Entrez Gene
- 5465
- UniGene
- 103110
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- nhr-38
- Caenorhabditis elegans
- sex-1
- Danio rerio
- pparaa
- Danio rerio
- pparab
- Mus musculus
- Ppara
- Rattus norvegicus
- Ppara
In other databases
- GenAge human genes
- This gene is present as PPARA
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Ppara
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs5766741
- Reference