LongevityMap Gene
Gene details
- HGNC symbol
- POLDIP3
- Aliases
- SKAR; PDIP46
- Common name
- DNA polymerase delta interacting protein 3
- Description
- This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- Cytogenetic Location
- 22q13.2
- UCSC Genome Browser
- View 22q13.2 on the UCSC genome browser
- OMIM
- 611520
- Ensembl
- ENSG00000100227
- UniProt/Swiss-Prot
- B4E0L0_HUMAN
- Entrez Gene
- 84271
- UniGene
- 505802
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- poldip3
- Drosophila melanogaster
- CG18259
- Drosophila melanogaster
- CG6961
- Mus musculus
- Poldip3
- Rattus norvegicus
- Poldip3
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- POLDIP3
- Reference