LongevityMap Gene

Gene details

HGNC symbol: PIK3R1
Aliases: p85; AGM7; GRB1; IMD36; p85-ALPHA
Common name: phosphoinositide-3-kinase regulatory subunit 1
Description: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Cytogenetic Location: 5q13.1
UCSC Genome Browser: View 5q13.1 on the UCSC genome browser
OMIM: 171833
Ensembl: ENSG00000145675
UniProt/Swiss-Prot: P85A_HUMAN
Entrez Gene: 5295
UniGene: 132225
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: aap-1
Danio rerio: pik3r1
Drosophila melanogaster: Pi3K21B
Mus musculus: Pik3r1
Rattus norvegicus: Pik3r1

In other databases

GenAge human genes

This gene is present as PIK3R1

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

Italian (Southern)

Study Design

A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).

Conclusions

After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.

Indentifier

rs1445760

Reference