LongevityMap Gene
Gene details
- HGNC symbol
- PIK3R1
- Aliases
- p85; AGM7; GRB1; IMD36; p85-ALPHA
- Common name
- phosphoinositide-3-kinase regulatory subunit 1
- Description
- Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
- Cytogenetic Location
- 5q13.1
- UCSC Genome Browser
- View 5q13.1 on the UCSC genome browser
- OMIM
- 171833
- Ensembl
- ENSG00000145675
- UniProt/Swiss-Prot
- P85A_HUMAN
- Entrez Gene
- 5295
- UniGene
- 132225
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- aap-1
- Danio rerio
- pik3r1
- Drosophila melanogaster
- Pi3K21B
- Mus musculus
- Pik3r1
- Rattus norvegicus
- Pik3r1
In other databases
- GenAge human genes
- This gene is present as PIK3R1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs1445760
- Reference