LongevityMap Gene
Gene details
- HGNC symbol
- PIK3CG
- Aliases
- PI3K; PIK3; PI3CG; PI3Kgamma; p110gamma; p120-PI3K
- Common name
- phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
- Description
- Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]
- Cytogenetic Location
- 7q22.3
- UCSC Genome Browser
- View 7q22.3 on the UCSC genome browser
- OMIM
- 601232
- Ensembl
- ENSG00000105851
- UniProt/Swiss-Prot
- A0A024R720_HUMAN
- Entrez Gene
- 5294
- UniGene
- 32942
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- age-1
- Danio rerio
- pik3cg
- Mus musculus
- Pik3cg
- Rattus norvegicus
- Pik3cg
- Saccharomyces cerevisiae
- VPS34
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as age-1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Japanese
- Study Design
- 1 intronic polymorphism was examined in 122 semisupercentenarians (older than 105, 107 female, 15 male, mean age 106.8 years) and 122 healthy younger controls (105 female, 17 male, mean age 33.33)
- Conclusions
- No significant differences relative to longevity were found
- Indentifier
- PIK3CG
- Reference