LongevityMap Gene
Gene details
- HGNC symbol
- PIK3CA
- Aliases
- MCM; CWS5; MCAP; PI3K; CLOVE; MCMTC; PI3K-alpha; p110-alpha
- Common name
- phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
- Description
- Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]
- Cytogenetic Location
- 3q26.32
- UCSC Genome Browser
- View 3q26.32 on the UCSC genome browser
- OMIM
- 171834
- Ensembl
- ENSG00000121879
- UniProt/Swiss-Prot
- PK3CA_HUMAN
- Entrez Gene
- 5290
- UniGene
- 553498
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- pik3ca
- Drosophila melanogaster
- Pi3K92E
- Mus musculus
- Pik3ca
- Rattus norvegicus
- AABR07037536.1
- Rattus norvegicus
- Pik3ca
- Saccharomyces cerevisiae
- VPS34
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as PIK3CA
- CellAge
- This gene is present as PIK3CA
Studies (2)
Significant/Non-significant: 1/1
Study 1
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- Studied genetic variation in the insulin/insulin-like growth factor signaling (IIS) pathway and in the telomere maintenance pathway for associations with longevity in 403 unrelated nonagenarians and 1,670 younger controls
- Conclusions
- SNP sets in both pathways were associated with longevity with the association of the IIS pathway defined by several genes (AKT1, AKT3, FOXO4, IGF2, INS, PIK3CA, SGK, SGK2, and YWHAG), while the telomere maintenance pathway seemed to be mainly determined by POT1 since only these genes showed an association with longevity
- Indentifier
- PIK3CA
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs870995
- Reference