LongevityMap Gene
Gene details
- HGNC symbol
- PER2
- Aliases
- FASPS; FASPS1
- Common name
- period circadian clock 2
- Description
- This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]
- Cytogenetic Location
- 2q37.3
- UCSC Genome Browser
- View 2q37.3 on the UCSC genome browser
- OMIM
- 603426
- Ensembl
- ENSG00000132326
- UniProt/Swiss-Prot
- PER2_HUMAN
- Entrez Gene
- 8864
- UniGene
- 58756
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- lin-42
- Danio rerio
- per2
- Drosophila melanogaster
- per
- Mus musculus
- Per2
- Rattus norvegicus
- Per2
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Per2
- GenAge microarray genes
- This gene is present as PER2
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Per2
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs2304672
- Reference