LongevityMap Gene
Gene details
- HGNC symbol
- PDPK1
- Aliases
- PDK1; PDPK2; PDPK2P; PRO0461
- Common name
- 3-phosphoinositide dependent protein kinase 1
- Description
- Cytogenetic Location
- 16p13.3
- UCSC Genome Browser
- View 16p13.3 on the UCSC genome browser
- OMIM
- 605213
- Ensembl
- ENSG00000140992
- UniProt/Swiss-Prot
- PDPK1_HUMAN
- Entrez Gene
- 5170
- UniGene
- 459691
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- pdk-1
- Danio rerio
- pdpk1a
- Danio rerio
- pdpk1b
- Drosophila melanogaster
- Pdk1
- Mus musculus
- Pdpk1
- Rattus norvegicus
- Pdpk1
- Saccharomyces cerevisiae
- PKH2
- Saccharomyces cerevisiae
- PKH3
- Saccharomyces cerevisiae
- PKH1
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as PDPK1
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as PKH2
- CellAge
- This gene is present as PDPK1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs758319
- Reference