LongevityMap Gene
Gene details
- HGNC symbol
- NOS2
- Aliases
- NOS; INOS; NOS2A; HEP-NOS
- Common name
- nitric oxide synthase 2
- Description
- Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 17q11.2
- UCSC Genome Browser
- View 17q11.2 on the UCSC genome browser
- OMIM
- 163730
- Ensembl
- ENSG00000007171
- UniProt/Swiss-Prot
- NOS2_HUMAN
- Entrez Gene
- 4843
- UniGene
- 709191
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- nos2b
- Danio rerio
- nos2a
- Drosophila melanogaster
- Nos
- Mus musculus
- Nos2
- Rattus norvegicus
- LOC497963
- Saccharomyces cerevisiae
- NCP1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- The variability of the three human genes (NOS1, NOS2, NOS3) was studied in a large sample (763 subjects, age range 19–107 years, median age 81 years). The sample analyzed included 417 females and 346 males.
- Conclusions
- None of the tested single nucleotide polymorphisms, excepting rs1879417, showed a significant association with the longevity phenotype. The NOS2 rs2297518 SNP was only marginally associated with longevity.
- Indentifier
- rs10459953
- Reference