LongevityMap Gene
Gene details
- HGNC symbol
- ND2
- Aliases
- MTND2
- Common name
- NADH dehydrogenase subunit 2
- Description
- Cytogenetic Location
- MT
- UCSC Genome Browser
- View MT on the UCSC genome browser
- OMIM
- 516001
- Ensembl
- UniProt/Swiss-Prot
- NU2M_HUMAN
- Entrez Gene
- 4536
- UniGene
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (2)
Significant/Non-significant: 1/1
Study 1
- Longevity Association
- Non-significant
- Population
- Chinese
- Study Design
- 5178A was genotyped for longevity association in 293 individuals representing three age groups (Old, n=95; Young, n=103; and Infant, n=95).
- Conclusions
- The 5178A distribution frequency difference between the age groups was not statistically significant (P>0.05)
- Indentifier
- 5178A
- Reference
Study 2
- Longevity Association
- Significant
- Population
- Japanese
- Study Design
- 11 Japanese centenarians and 43 controls were sequenced to identify the substitution differences between centenarians and controls. Then the identified variants were examined in 37 centenarians and 252 healthy controls.
- Conclusions
- The frequency of Mt5178A was significantly higher in centenarians (23/37, 62%) than in blood donors (114/252, 45% p=0.04, odds ratio 1.99). Mt5178A was related to longevity. Mt5178C carriers were more susceptible to adult-onset diseases than those with Mt5178A.
- Indentifier
- Mt5178A/C
- Reference