LongevityMap Gene
Gene details
- HGNC symbol
- NCAM2
- Aliases
- NCAM21
- Common name
- neural cell adhesion molecule 2
- Description
- The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 21q21.1
- UCSC Genome Browser
- View 21q21.1 on the UCSC genome browser
- OMIM
- 602040
- Ensembl
- ENSG00000154654
- UniProt/Swiss-Prot
- NCAM2_HUMAN
- Entrez Gene
- 4685
- UniGene
- 473450
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- ncam-1
- Danio rerio
- NCAM2 (1 of many)
- Danio rerio
- ncam2
- Drosophila melanogaster
- Fas2
- Mus musculus
- Ncam2
- Rattus norvegicus
- Ncam2
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study using 1,471 genotyped participants from the Framingham Heart Study, of which 1,173 individuals had known lifespans, plus 517 individuals from the Offspring cohort for validating connections between longevity and genetic variants
- Conclusions
- A total of 27 SNPs, including in CDH4, SVEP1, CACNA1C, CARS, STK24, C7orf50, PARVG, NCAM2, PPP2R2C, NLRC5, BTBD9, RAC2, TGFA, KIAA0649, ABCC4, CLSTN2, FAM19A5 and RUNX3, were identified at the intersection of various statistical procedures
- Indentifier
- rs2826891
- Reference