LongevityMap Gene

Gene details

HGNC symbol: NAT2
Aliases: AAC2; PNAT; NAT-2
Common name: N-acetyltransferase 2
Description: This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008]
Cytogenetic Location: 8p22
UCSC Genome Browser: View 8p22 on the UCSC genome browser
OMIM: 612182
Ensembl: ENSG00000156006
UniProt/Swiss-Prot: A4Z6T7_HUMAN
Entrez Gene: 10
UniGene: 2
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: si:dkey-78a14.4
Danio rerio: zgc:101040
Mus musculus: Nat3
Rattus norvegicus: Nat3

Studies (3)

Significant/Non-significant: 0/3

Study 1

Longevity Association

Non-significant

Population

Study Design

The enzymatic polymorphism was examined in 41 nonagenarians (10 males, mean age 92.2 years, range 90-98) free of known malignancies or neurodegenerative diseases and in control groups comprised of 217 healthy volunteers (128 males, mean age 36.3 years)

Conclusions

No association with longevity was found

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Study Design

NAT25A (C481T), NAT26A (G590A), NAT27A (G857A), and NAT214A (G191A) SNPs were examined in 552 centenarians and 243 controls aged 20-70 years

Conclusions

No significant difference was found between centenarian and control subjects with respect to allelic variant frequencies, genotype distributions or predicted phenotypes deduced from genotype combinations

Indentifier

Reference

Study 3

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier