LongevityMap Gene
Gene details
- HGNC symbol
- NAT1
- Aliases
- AAC1; MNAT; NATI; NAT-1
- Common name
- N-acetyltransferase 1
- Description
- This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
- Cytogenetic Location
- 8p22
- UCSC Genome Browser
- View 8p22 on the UCSC genome browser
- OMIM
- 108345
- Ensembl
- ENSG00000171428
- UniProt/Swiss-Prot
- ARY1_HUMAN
- Entrez Gene
- 9
- UniGene
- 591847
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- zgc:101040
- Danio rerio
- si:dkey-78a14.4
- Mus musculus
- Nat2
- Mus musculus
- Nat1
- Rattus norvegicus
- Nat1
- Rattus norvegicus
- Nat2
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs1057126
- Reference