LongevityMap Gene
Gene details
- HGNC symbol
- MRPL37
- Aliases
- L2mt; L37mt; MRPL2; RPML2; MRP-L2; MRP-L37
- Common name
- mitochondrial ribosomal protein L37
- Description
- Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 1p32.3
- UCSC Genome Browser
- View 1p32.3 on the UCSC genome browser
- OMIM
- 611843
- Ensembl
- ENSG00000116221
- UniProt/Swiss-Prot
- RM37_HUMAN
- Entrez Gene
- 51253
- UniGene
- 584908
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenAge microarray genes
- This gene is present as MRPL37
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- Genome-wide association study in 403 unrelated nonagenarians from long-living families and 1670 younger controls. Strongest candidates were then investigated in a meta-analysis of 4149 nonagenarian cases and 7582 younger controls.
- Conclusions
- No SNP reached significance in the GWAS but 62 SNPs, many in genes, had an indicative association with survival into old age. Of these 62 SNPs then studied in the meta-analysis, 61 were not significant.
- Indentifier
- rs642990
- Reference