LongevityMap Gene

Gene details

HGNC symbol: MOG
Aliases: BTN6; BTNL11; MOGIG2; NRCLP7
Common name: myelin oligodendrocyte glycoprotein
Description: The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 6p22.1
UCSC Genome Browser: View 6p22.1 on the UCSC genome browser
OMIM: 159465
Ensembl: ENSG00000204655
UniProt/Swiss-Prot: MOG_HUMAN
Entrez Gene: 4340
UniGene: 141308
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: cabz01076234.2
Danio rerio: zgc:123297
Danio rerio: CABZ01059909.1
Danio rerio: zgc:175177
Danio rerio: CABZ01059909.2
Danio rerio: CABZ01059912.2
Danio rerio: zgc:162154
Mus musculus: Mog
Rattus norvegicus: Mog

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

German

Study Design

Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).

Conclusions

Fifteen SNPs had indicative association with longevity, even if not statistically significant after correcting for multiple hypothesis testing. None of these SNPs were validated in the follow-up analysis. Since rs12741354 (in ASTN1) was nearly significant, it was further investigated in French centenarians but it failed to be associated with longevity.

Indentifier

rs29228

Reference