LongevityMap Gene
Gene details
- HGNC symbol
- MLST8
- Aliases
- GBL; LST8; POP3; WAT1; GbetaL
- Common name
- MTOR associated protein, LST8 homolog
- Description
- Cytogenetic Location
- 16p13.3
- UCSC Genome Browser
- View 16p13.3 on the UCSC genome browser
- OMIM
- 612190
- Ensembl
- ENSG00000167965
- UniProt/Swiss-Prot
- LST8_HUMAN
- Entrez Gene
- 64223
- UniGene
- 29203
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- C10H11.8
- Danio rerio
- mlst8
- Drosophila melanogaster
- Lst8
- Mus musculus
- Mlst8
- Rattus norvegicus
- Mlst8
- Saccharomyces cerevisiae
- LST8
- Schizosaccharomyces pombe
- wat1
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- MLST8
- Reference