LongevityMap Gene
Gene details
- HGNC symbol
- MKRN2
- Aliases
- RNF62; HSPC070
- Common name
- makorin ring finger protein 2
- Description
- This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
- Cytogenetic Location
- 3p25.2
- UCSC Genome Browser
- View 3p25.2 on the UCSC genome browser
- OMIM
- 608426
- Ensembl
- ENSG00000075975
- UniProt/Swiss-Prot
- MKRN2_HUMAN
- Entrez Gene
- 23609
- UniGene
- 591666
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- Y55F3AM.6
- Danio rerio
- mkrn2
- Drosophila melanogaster
- CG5334
- Drosophila melanogaster
- Mkrn1
- Drosophila melanogaster
- CG5347
- Drosophila melanogaster
- CG12477
- Mus musculus
- Mkrn2
- Rattus norvegicus
- Mkrn2
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs15997
- Reference