LongevityMap Gene

Gene details

HGNC symbol: MAPK3
Aliases: ERK1; ERT2; ERK-1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK
Common name: mitogen-activated protein kinase 3
Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 16p11.2
UCSC Genome Browser: View 16p11.2 on the UCSC genome browser
OMIM: 601795
Ensembl: ENSG00000102882
UniProt/Swiss-Prot: L7RXH5_HUMAN
Entrez Gene: 5595
UniGene: 861
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: mpk-1
Danio rerio: mapk3
Drosophila melanogaster: rl
Mus musculus: Mapk3
Rattus norvegicus: Mapk3
Saccharomyces cerevisiae: KSS1
Saccharomyces cerevisiae: FUS3
Schizosaccharomyces pombe: spk1

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as KSS1
A homolog of this gene for Caenorhabditis elegans is present as mpk-1

GenAge human genes

This gene is present as MAPK3

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

Italian (Southern)

Study Design

A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).

Conclusions

After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.

Indentifier

rs7542

Reference