LongevityMap Gene
Gene details
- HGNC symbol
- MAPK1
- Aliases
- ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK
- Common name
- mitogen-activated protein kinase 1
- Description
- This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
- Cytogenetic Location
- 22q11.22
- UCSC Genome Browser
- View 22q11.22 on the UCSC genome browser
- OMIM
- 176948
- Ensembl
- ENSG00000100030
- UniProt/Swiss-Prot
- MK01_HUMAN
- Entrez Gene
- 5594
- UniGene
- 431850
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- mpk-1
- Danio rerio
- mapk1
- Drosophila melanogaster
- rl
- Mus musculus
- Mapk1
- Rattus norvegicus
- Mapk1
- Saccharomyces cerevisiae
- FUS3
- Saccharomyces cerevisiae
- KSS1
In other databases
- GenAge model organism genes
- CellAge
- This gene is present as MAPK1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Chinese
- Study Design
- A 10-year follow-up study of the Chinese longitudinal healthy longevity survey was performed consisting of 963 long-lived and 1028 geography-matched young individuals. Sixteen SNPs from ADRB1, ADRB2, ADCY5, ADCY6, and MAPK1 were selected and genotyped.
- Conclusions
- None of the tested single nucleotide polymorphisms, excepting rs1042718 (C/A) and rs1042719 (G/C), showed a significant association with the longevity phenotype
- Indentifier
- rs5749998
- Reference