LongevityMap Gene
Gene details
- HGNC symbol
- LOC107987209
- Aliases
- Common name
- uncharacterized LOC107987209
- Description
- Cytogenetic Location
- 14q32.33
- UCSC Genome Browser
- View 14q32.33 on the UCSC genome browser
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 107987209
- UniGene
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
No homologs found
Studies (2)
Significant/Non-significant: 1/1
Study 1
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- Genome-wide association study in 403 unrelated nonagenarians from long-living families and 1670 younger controls. Strongest candidates were then investigated in a meta-analysis of 4149 nonagenarian cases and 7582 younger controls.
- Conclusions
- rs2498804 in AKT1 also showed a significant association with survival into old age
- Indentifier
- rs2498804
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs2498802
- Reference