LongevityMap Gene
Gene details
- HGNC symbol
- LOC105378963
- Aliases
- Common name
- uncharacterized LOC105378963
- Description
- Cytogenetic Location
- 5q11.2
- UCSC Genome Browser
- View 5q11.2 on the UCSC genome browser
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105378963
- UniGene
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
No homologs found
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
- Conclusions
- Fifteen SNPs had indicative association with longevity, even if not statistically significant after correcting for multiple hypothesis testing. None of these SNPs were validated in the follow-up analysis. Since rs12741354 (in ASTN1) was nearly significant, it was further investigated in French centenarians but it failed to be associated with longevity.
- Indentifier
- rs350450
- Reference