LongevityMap Gene

Gene details

HGNC symbol: IL12B
Aliases: CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B
Common name: interleukin 12B
Description: This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 5q33.3
UCSC Genome Browser: View 5q33.3 on the UCSC genome browser
OMIM: 161561
Ensembl: ENSG00000113302
UniProt/Swiss-Prot: IL12B_HUMAN
Entrez Gene: 3593
UniGene: 674
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: il12ba
Danio rerio: il12bb
Danio rerio: CABZ01013771.1
Danio rerio: il12bb
Mus musculus: Il12b
Rattus norvegicus: Il12b

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

Italian (Southern)

Study Design

A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).

Conclusions

After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.

Indentifier

rs17875322

Reference