LongevityMap Gene

Gene details

HGNC symbol: IL10
Aliases: CSIF; TGIF; GVHDS; IL-10; IL10A
Common name: interleukin 10
Description: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
Cytogenetic Location: 1q32.1
UCSC Genome Browser: View 1q32.1 on the UCSC genome browser
OMIM: 124092
Ensembl: ENSG00000136634
UniProt/Swiss-Prot: IL10_HUMAN
Entrez Gene: 3586
UniGene: 193717
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: il10
Mus musculus: Il10
Rattus norvegicus: Il10

Studies (9)

Significant/Non-significant: 4/5

Study 1

Longevity Association

Non-significant

Population

Study Design

250 (52 males and 198 females) nonagenarians and 400 healthy control group (18-60 years old) were examined for 1082 SNP

Conclusions

No significant differences relative to longevity were found

Indentifier

Reference

Study 2

Longevity Association

Population

Study Design

The -1082G/A, -819C/T and -592C/A proximal promoter SNPs were examined in 190 centenarians (>99 years old, 159 women and 31 men) and in 260 control subjects (99 women and 161 men less than 60 years old)

Conclusions

The -1082G homozygous genotype, associated with high IL-10 production, was increased in centenarian men but not in centenarian women. No difference was found between centenarians and control subjects regarding the other two SNPs.

Indentifier

Reference

Study 3

Longevity Association

Population

Study Design

-1082 G/A SNP was examined in 72 centenarian men, 102 centenarian women and healthy unrelated controls (115 men and 112 women, aged 22-60 years)

Conclusions

The number of male centenarians homozygous for the -1082G genotype, suggested to be associated with high IL-10 production, was significantly increased in comparison with younger control subjects. No significant differences were observed between women and controls.

Indentifier

Reference

Study 4

Longevity Association

Non-significant

Population

Study Design

100 control samples (59% female and 41% male) and 93 aged consecutive samples (70% female, 30% male with an age range of 80-97 years) were analyzed for -1082G/A SNP

Conclusions

No significant differences were observed in centenarians and controls

Indentifier

Reference

Study 5

Longevity Association

Non-significant

Population

Italian (Sardinia)

Study Design

112 (36 male, 76 female) centenarians, as well as 137 sixty-year-old controls, were analyzed for -1082G/A SNP

Conclusions

No significant differences were observed in centenarians and controls

Indentifier

Reference

Study 6

Longevity Association

Population

Study Design

-819 T/C SNP was evaluated with age or gender in 500 Japanese persons (mean age: 56.7 years old, range: 19-100)

Conclusions

There was a significant association of -819 T/C with age

Indentifier

Reference

Study 7

Longevity Association

Population

Study Design

IL-10 -1082 G/A and TNF-alpha-308 G/A were genotyped in 119 randomly selected elderly subjects (41 women and 78 men) with a mean age of 90.2 years and young control subjects of 118 (46 women and 72 men) with a mean age of 31.9 years

Conclusions

No significant differences were found in the genotype and allele frequencies of TNF-alpha gene variants between the two groups (P > 0.05). IL-10 genotype and allele frequencies were significantly associated with longevity in men (P < 0.05) but not in women (P < 0.05).

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Reference

Study 8

Longevity Association

Non-significant

Population

Study Design

-1082G/A, -819 C/T and -592 C/A SNPs were examined in 17 unrelated elderly (age 65-90 years; 6 males and 11 females), 23 family members (age 18-57 years; 9 males and 14 females, and a control group with 105 randomly selected, matched for geographical dist

Conclusions

Genotype -1082G/A, -819 C/C, -592 C/C was positively associated, while genotype -1082A/A, -819 C/T, -592 C/A, was negatively associated with longevity in Bulgarians. The results, however, were not statistically significant.

Indentifier

Reference

Study 9

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier