LongevityMap Gene

Gene details

HGNC symbol: IFNG
Aliases: IFG; IFI
Common name: interferon gamma
Description: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
Cytogenetic Location: 12q15
UCSC Genome Browser: View 12q15 on the UCSC genome browser
OMIM: 147570
Ensembl: ENSG00000111537
UniProt/Swiss-Prot: IFNG_HUMAN
Entrez Gene: 3458
UniGene: 856
1000 Genomes: 1000 Genomes

Homologs in model organisms

Mus musculus: Ifng
Rattus norvegicus: Ifng

In other databases

CellAge

This gene is present as IFNG

Studies (6)

Significant/Non-significant: 2/4

Study 1

Longevity Association

Population

Study Design

The distribution of the 874T/A polymorphism was examined in 174 Italian centenarians (>99 years old, 142 women and 32 men) and 248 <60-year-old control subjects (90 women and 158 men)

Conclusions

The +874T allele, known to be associated with low IFN-gamma production, was found less frequently in centenarian women than in centenarian men or in control women whereas no significant differences were observed in the distribution of the two alleles between male or female controls. Allele frequencies in centenarian men were not found significantly different from male controls.

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Study Design

100 control samples (59% female and 41% male) and 93 aged consecutive samples (70% female, 30% male with an age range of 80-97 years) were analyzed for Intron I microsatellite repeats

Conclusions

No significant differences were observed between centenarians and controls

Indentifier

Reference

Study 3

Longevity Association

Non-significant

Population

Study Design

874T/A SNP was examined in 17 unrelated elderly (age 65-90 years; 6 males and 11 females), 23 family members (age 18-57 years; 9 males and 14 females, and a control group with 105 randomly selected, matched for geographical distribution healthy controls aged 25-53 years (40 male and 65 female)

Conclusions

No significant association with longevity was found

Indentifier

Reference

Study 4

Longevity Association

Non-significant

Population

Italian (Sardinia)

Study Design

112 (36 male, 76 female) centenarians, as well as 137 sixty-year-old controls, were analyzed for 874T/A SNP

Conclusions

No significant differences were observed between centenarians and controls

Indentifier

Reference

Study 5

Longevity Association

Population

Study Design

The distribution of 874T/A polymorphism was examined in 174 Italian centenarians (>99 years old, 142 women) and 248 <60-year-old control subjects (90 women)

Conclusions

The +874T allele, known to be associated with low IFN-gamma production, was found less frequently in centenarian women than in centenarian men or in control women (p=0.02) whereas no significant differences were observed in the distribution of the two alleles between male or female controls. Allele frequencies in centenarian men were not found significantly different from male controls.

Indentifier

Reference

Study 6

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier