LongevityMap Gene
Gene details
- HGNC symbol
- HTR2A
- Aliases
- HTR2; 5-HT2A
- Common name
- 5-hydroxytryptamine receptor 2A
- Description
- This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
- Cytogenetic Location
- 13q14.2
- UCSC Genome Browser
- View 13q14.2 on the UCSC genome browser
- OMIM
- 182135
- Ensembl
- ENSG00000102468
- UniProt/Swiss-Prot
- 5HT2A_HUMAN
- Entrez Gene
- 3356
- UniGene
- 72630
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- ser-1
- Danio rerio
- htr2ab
- Danio rerio
- htr2aa
- Drosophila melanogaster
- 5-HT2B
- Mus musculus
- Htr2a
- Rattus norvegicus
- Htr2a
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as ser-1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs6306
- Reference