LongevityMap Gene
Gene details
- HGNC symbol
- HMGB1
- Aliases
- HMG1; HMG3; HMG-1; SBP-1
- Common name
- high mobility group box 1
- Description
- This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]
- Cytogenetic Location
- 13q12.3
- UCSC Genome Browser
- View 13q12.3 on the UCSC genome browser
- OMIM
- 163905
- Ensembl
- ENSG00000189403
- UniProt/Swiss-Prot
- A0A024RDR0_HUMAN
- Entrez Gene
- 3146
- UniGene
- 434102
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- hmg-1.2
- Danio rerio
- hmgb1b
- Danio rerio
- hmgb1a
- Drosophila melanogaster
- Dsp1
- Rattus norvegicus
- Hmg1l1
- Rattus norvegicus
- AC135696.1
- Saccharomyces cerevisiae
- NHP6A
- Saccharomyces cerevisiae
- NHP6B
In other databases
- GenAge human genes
- This gene is present as HMGB1
- CellAge
- This gene is present as HMGB1
- CellAge gene expression
- This gene is present as HMGB1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs3742305
- Reference