LongevityMap Gene
Gene details
- HGNC symbol
- FAM19A5
- Aliases
- TAFA5; TAFA-5; UNQ5208; QLLK5208
- Common name
- family with sequence similarity 19 member A5, C-C motif chemokine like
- Description
- This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Sep 2013]
- Cytogenetic Location
- 22q13.32
- UCSC Genome Browser
- View 22q13.32 on the UCSC genome browser
- OMIM
- Ensembl
- ENSG00000219438
- UniProt/Swiss-Prot
- F19A5_HUMAN
- Entrez Gene
- 25817
- UniGene
- 436854
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study using 1,471 genotyped participants from the Framingham Heart Study, of which 1,173 individuals had known lifespans, plus 517 individuals from the Offspring cohort for validating connections between longevity and genetic variants
- Conclusions
- A total of 27 SNPs, including in CDH4, SVEP1, CACNA1C, CARS, STK24, C7orf50, PARVG, NCAM2, PPP2R2C, NLRC5, BTBD9, RAC2, TGFA, KIAA0649, ABCC4, CLSTN2, FAM19A5 and RUNX3, were identified at the intersection of various statistical procedures
- Indentifier
- rs5771675
- Reference